One of the important issues in any revolution is the careful investigation of the bottlenecks of the enemies of that revolution with the aim of preventing it. The aim of the current research is to investigate the main groups that are coveted by the enemies of the Islamic Republic of Iran in the eyes of the Supreme Leader. The main question is which sections of the society are more vulnerable to the influence of the enemies and their abuse, and what recommendations does the leader of the revolution have for these groups to stay safe from deviation? This research has investigated this issue with an analytical-descriptive method and by using library sources and also based on data collection from the collection of his statements and speeches. The findings of the above research are as follows: The most important groups that the leadership addresses and warns against the influence of the enemy are the four groups of officials, clerics, academics and the press. Gaining insight, relying on God and not forgetting his memory in all matters of life, striving on two fronts (internal jihad), empathy and efficiency of officials, the need to plan according to the plans of the enemy,